Bio & Research Interests:
Jim Wager-Miller earned his B.S. in Biochemistry and M.S. in Chemistry from Western Washington University. His journey in research commenced with the study of polycystic kidney disease at Children's Hospital and at the University of Washington in Seattle.
Since 2000, Jim has been an integral part of Dr. Ken Mackie's lab, dedicated to exploring the effects of cannabinoids in the central and peripheral nervous systems. His research spans various facets of cannabinoid biology, as evidenced by his extensive contributions in scientific literature. Jim's expertise in laboratory techniques related to the endocannabinoid system has been documented in his publications, collaborating frequently with Dr. Mackie. Moreover, his research extends to understanding receptor dimerization, differential signaling of cannabinoids at G protein-coupled receptors, and the impact of cannabis exposure during important developmental periods.
Jim Wager-Miller's scientific journey showcases a commitment to understanding the complex interactions of cannabinoids with biological systems, making significant strides in elucidating their roles and potential therapeutic applications.
Representative publications:
Full list of publications- Sexually Dimorphic Adolescent Trajectories of Prefrontal Endocannabinoid Synaptic Plasticity Equalize in Adulthood, Reflected by Endocannabinoid System Gene Expression. Bernabeu A, Bara A, Murphy Green MN, Manduca A, Wager-Miller J, Borsoi M, Lassalle O, Pelissier-Alicot AL, Chavis P, Mackie K, Manzoni OJJ. Cannabis Cannabinoid Res. 2023 Oct;8(5):749-767. doi: 10.1089/can.2022.0308. Epub 2023 Apr 4. PMID: 37015060
- Quantitation of Plasma Membrane (G Protein-Coupled) Receptor Trafficking in Cultured Cells. Wager-Miller J, Mackie K. Methods Mol Biol. 2023;2576:395-406. doi: 10.1007/978-1-0716-2728-0_33. PMID: 36152205
- Effects of Tetrahydrocannabinol and Cannabidiol on Brain-Derived Neurotrophic Factor and Tropomyosin Receptor Kinase B Expression in the Adolescent Hippocampus. Winstone J, Shafique H, Clemmer ME, Mackie K, Wager-Miller J. Cannabis Cannabinoid Res. 2023 Aug;8(4):612-622. doi: 10.1089/can.2021.0025. Epub 2022 May 30. PMID: 35639364
- The modulatory role of cannabis use in subconcussive neural injury. Kalbfell RM, Rettke DJ, Mackie K, Ejima K, Harezlak J, Alexander IL, Wager-Miller J, Johnson BD, Newman SD, Kawata K. Iscience. 2023 Jun 16;26(6).
- Western Blotting of the Endocannabinoid System. Wager-Miller J, Mackie K. Methods Mol Biol. 2023;2576:385-393. doi: 10.1007/978-1-0716-2728-0_32. PMID: 36152204
- Design, synthesis, and evaluation of substituted alkylindoles that activate G protein-coupled receptors distinct from the cannabinoid CB1 and CB2 receptors. Kline T, Xu C, Kreitzer FR, Hurst DP, Eldeeb KM, Wager-Miller J, Olivas K, Hepburn SA, Huffman JW, Mackie K, Howlett AC, Reggio P, Stella N. Eur J Med Chem. 2023 Mar 5;249:115123. doi: 10.1016/j.ejmech.2023.115123. Epub 2023 Jan 26. PMID: 36708677