Yunlong Liu, Ph.D., of Indiana University's School of Medicine will present a lecture entitled: Roles of regulatory variants in complex diseases.
Abstract: Alternative splicing (AS) is a closely regulated process that allows a single gene to encode multiple protein isoforms, thereby contributing to the diversity of the proteome. Dysregulation of the splicing process has been found to be associated with many inherited diseases. In this talk, Dr. Liu will discuss several projects that involve computational modeling in the regulation and functions of alternative splicing, including the roles of synonymous and intronic SNPs in complex disease, the clinical impact of splicing regulation on cancer prognosis, and the roles of protein structure prediction in understanding the functions of splicing variants. In addition, he will also discuss several ongoing projects in his laboratory that use high-throughput reporter assays in screening the functional variants in complex diseases..