Jui-Yen Huang, Ph.D. of the Lu Lab at Indiana University Bloomington will present a lecture entitled: The Impact of Dysregulated FGF-FGFR signaling in Post-mitotic Neuron During Cortical Development.
Abstract: A functional brain is reliant on proper communication between neurons; thus, brain function is determined by precise cellular connectivity. Given the importance of accurate brain wiring, aberrant brain circuitry, either misconnections or disrupted connections, is the primary cause of neurological diseases. As the demand increases to repair brain circuitry, my primary research interest is to identify factors that are essential for circuitry assembling and are capable to re-wire brain circuitry. My current research focuses on the function of the fibroblast growth factor (FGF) family in cortical development. The FGF family is composed of 22 ligands and 5 receptors. In the brain, the FGF family was found to regulate neural development through neurogenesis and brain patterning. Subsequent observations implicated that the FGF family also monitors neurogenesis in adult animals. Nevertheless, the function of specific FGF-FGFR signaling in relation to brain circuitry remains unclear. FGFs/FGFRs dysregulation is related to several neurological diseases, such as anxiety, schizophrenia, depression, brain tumors, Alzheimer's disease (AD), and Parkinson's disease (PD). However, the casual relationship between dysregulated FGF-FGFR signaling and its contribution to neurological disease remains to be elaborated. To address this, I extensively employ genetic approach combined with in-utero electroporation to manipulate the expression levels of FGFs and FGFRs and examine their roles in brain at anatomical and functional levels. I will share our recent progresses with you.