Deborah Clegg of Drexel Medical Center will present a lecture entitled: Sex Differences in Metabolism: Critical Role of Sex Chromosomes and Sex Hormones.
Abstract: Most pre-clinical and clinical, animal and human medical research has been biased with respect to sex. The focus of this presentation will be on the critical need to incorporate sex and gender in pre-clinical and clinical research to enhance our understanding of the mechanisms by which metabolic processes differ by sex and gender. This knowledge will allow for the development of personalized medicine which will optimize therapies specific for individuals. To elucidate this, I will focus on what is both known and not known about the contribution of sex hormones and chromosomes on metabolism. I will also highlight data suggesting that males and females may process nutrients differently. I will conclude by making the call for enhancing our knowledge of how, when, and under what context sex hormones may influence metabolic processes and nutrient absorption by highlighting data focusing on cross hormone therapy in individuals whose sex chromosomes do not align with their circulating sex hormones.